The pregnane x receptor

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August undefined, 2024

Webb15 juli 2008 · Background: The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters … WebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and Vascular Biology has examined the potential for PXR to regulate hepatic apoA-I and HDL formation in response to bileacids.12 Wild-typemice,miceinwhichthePXRgenehad

Pregnane X Receptor: Understanding Its Function and Activity at …

Webb30 juni 2024 · Pregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is … WebbPregnane X receptor (PXR, NR1I2) is activated by various chemically unrelated compounds, including environmental pollutants and drugs. We proceeded here to in vitro screening of … irf7389trpbf

Receptor X de pregnano - Wikipedia, la enciclopedia libre

WebbThe pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals. PXR is activated by a structurally diverse … WebbThe nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including foreign chemicals … ordering picture prints

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross …

Nutritional calcium modulates colonic expression of vitamin D …

WebbIn the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor... WebbFarnesoid X receptor (FXR), a member of the nuclear receptor superfamily that is mainly expressed in enterohepatic tissues, has been discovered as a crucial regulator for balancing liver inflammatory processes and metabolism [ 5, 6, 7] and thus has become a pharmacological target for liver disorders. ordering pictures online from walgreensWebb18 mars 2009 · Pregnane X receptor (PXR) is an important component of the body's adaptive defense system responsible for the elimination of various toxic xenobiotics. … ordering pictures in frames

"Webb关键词：孕烷X 受体；CYP3A4；药物代谢中图分类号：R969.1 文献标志码：A 文章编号：1007-7693(2013)12-1357-03 Role of Pregnane X Receptor(PXR) in Drug Metabolism … " - The pregnane x receptor

The pregnane x receptor

Nutritional calcium modulates colonic expression of vitamin D receptor …

Webb19 jan. 2024 · The pregnane X receptor (PXR) is implicated in fatty liver, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory … WebbAbstract Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear …

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WebbPregnane X Receptor (PXR), a member of the nuclear receptor (NR) superfamily, discovered in 1998 , represents a modular protein sharing common regions, a highly … Webb2 okt. 2024 · Nuclear receptors such as the Pregnane X Receptor (PXR) are known to be key regulators of ABC drug transporters such as Abcb1, Abcc2, Abcc3, and Abcg2 [ 25, 26, 27, 28 ]. It is well known that PXR is activated by endogenous steroidal hormones and their metabolites, the levels of which are dramatically elevated during pregnancy.

Webb29 sep. 2014 · Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. The aim of the current study was to … WebbThe pregnane X-receptor (PXR) and the constitutive androstane receptor (CAR) are orphan nuclear receptors activated by a variety of ligands ( Kretschmer and Baldwin, 2005 ). …

Webb28 juni 2013 · Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug … http://www.paper.edu.cn/scholar/showpdf/MUT2QNyIMTD0YxeQh

Webb1 juli 2005 · THE PREGNANE X RECEPTOR (PXR; NR1I2), a member of the nuclear hormone receptor (NR) superfamily, is a key regulator of bile salt, steroid hormone, and xenobiotic …

Webb1 juli 2024 · The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including … irf7401 datasheetWebbThe pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma; Cellular Differentiation of … irf7343p datasheetWebbBackground: The pregnane X receptor (PXR) is a nuclear receptor (NR) involved in the detoxification of xenobiotic compounds via upregulation of cytochrome P450 enzyme … irf7380trpbfWebb1 nov. 2006 · The pregnane X receptor (PXR) is a major chemical sensor known to activate the expression of CYP3A/Cyp3a in humans and rodents. The purpose of this study is to … irf7350trpbfWebb29 sep. 2024 · The pregnane X receptor (PXR, NR1I2) is a ligand-activated transcription factor and a member of the nuclear receptor (NR) superfamily [].As part of the … irf7343trpbfWebb15 okt. 2024 · Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is … irf7401pbfWebb1 apr. 2024 · Background. The pregnane X receptor (PXR) is a xenobiotic sensing nuclear receptor that is activated by a diverse array of substances, including environmental … irf730pbf