WebAcyl carrier protein (ACP) is the carrier of fatty acids during their synthesis and utilization. ACPs (or ACP-like protein domains) have been found throughout biology and share significant amino acid sequence similarities. All ACPs undergo a post-translational modification in which 4′-phosphopantetheine is transferred from CoA to a specific serine … WebJun 13, 2005 · Phosphopantetheine adenylyltransferase Molecular Weight 17707.325 Da. References. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Phosphopantetheine - Wikipedia
Web4'-Phosphopantetheine C11H23N2O7PS CID 115254 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... WebCHAPTER Extracellular 4’-Phosphopantetheine is a source for intracellular coenzyme A synthesis Balaji Srinivasan 1, Madina Baratashvili, Marianne van der Zwaag 1, Bart Kanon, Cristina Colombelli2, Roald A Lambrechts 1, Onno Schaap, Ellen A Nollen3, Ajda Podgoršek 4, Gregor Kosec , Hrvoje Petković, Susan Hayflick5, Valeria Tiranti2, Dirk-Jan Reijngoud6, five letter words ending with ac
4
WebThe phosphopantetheine prosthetic group of ACP, fatty acid synthetase complexes, and presumably other enzyme systems, turn over rapidly, possibly as part of a cellular control … WebMar 2, 2024 · Here we report the discovery and hit-to-lead optimization of new inhibitors of phosphopantetheine adenylyltransferase (PPAT) from Gram-negative bacteria. Utilizing a fragment-based screening approach, we discovered a number of unique scaffolds capable of interacting with the pantetheine site of E. coli PPAT and inhibiting enzymatic activity ... WebSep 17, 2015 · Coenzyme A (CoA) acts as the universal acyl carrier in metabolism, either directly or by providing the 4′-phosphopantetheine moiety of acyl and peptidyl carrier proteins 1, 2. It is ... five letter words ending with ack