Lineage tracing reveals metastatic dynamics

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August undefined, 2024

NettetTumour cells are subjected to evolutionary selection pressures during progression from initiation to metastasis. ... Multicolour lineage tracing reveals clonal dynamics of … Nettet1. jun. 2024 · To study cancer metastasis at high resolution, Simeonov et al. [2] developed a genetic system based on an inducible lineage tracer coupled with single-cell RNA-seq and applied it to an in vivo ...

Marker-free lineage tracing reveals an environment-instructed ...

Nettet1. jun. 2024 · Download Citation Lineage tracing reveals metastatic dynamics Combining single-cell lineage tracing with RNA sequencing has provided … Nettet5. nov. 2024 · Once established, CRISPR–Cas9-based genetic lineage tracing was used to study the clonal dynamics of various biological systems. scGESTALT was applied to zebrafish brains and used to unravel ... how to measure a cylinder bore

Evolving barcodes shed light into evolving metastases

Nettet10. sep. 2024 · Overall, this study reveals clonal dynamics during each step of tumor progression, from initiation to growth, recurrence, and distant metastasis. Keywords: cancer metastasis; clonal evolution; lineage tracing; sarcoma; suppressors of metastasis; tumor heterogeneity. Copyright © 2024 The Author(s). Published by … NettetCombining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In this issue of … Nettet10. jun. 2024 · Lineage reconstruction in a metastatic pancreatic cancer model reveals extensive bottlenecking and subpopulation signaling, as well as specific transcriptional states associated with metastatic … mullion style card reader

Lineage tracing reveals metastatic dynamics - PubMed

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Nettet12. apr. 2024 · To determine this lineage development relationship, we used an inducible genetic lineage tracing system for CD34 + cells by crossing Cd34-CreER T2 with R26-tdTomato mouse lines . The resulting Cd34 -CreER T2 ;R26-tdTomato mice were treated with tamoxifen to induce tdTomato labeling of CD34 + cells, and then the hindlimb … Nettet5. mar. 2024 · Metastatic dynamics are revealed by integrating single-cell lineage tracing and RNA sequencing. Cancer evolution is highly dynamic. Clones and subclones may expand, shrink, and spread to different ... how to measure adaptabilityNettet15. feb. 2024 · Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and the fourth leading cause of cancer-related death globally. Tumor cells recruit and remodel various types of stromal and inflammatory cells to form a tumor microenvironment (TME), which encompasses cellular and molecular entities, including … mullion to st ives

"Nettet1. jun. 2024 · Recently, several lineage tracing approaches have emerged that are able to link clonal identity with gene expression by utilising expressed genetic barcodes that … " - Lineage tracing reveals metastatic dynamics

Lineage tracing reveals metastatic dynamics

Nettet25. jul. 2024 · It is worth noting that because the present study traced tumor dynamics following multiple (simultaneous) initiating insults and relies on harvesting the primary tumor and any metastatic lesions to recover lineage relationships, pre-malignant clonal dynamics are obscured in this system. NettetCombining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In this issue of Cancer Cell, Simeonov et al. developed the macsGESTALT lineage recording system to reveal that hybrid EMT states and S100 expression are associated with elevated metastatic …

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Nettet25. mai 2024 · Reeves, M.Q., Kandyba, E., Harris, S. et al. Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to … Nettet16. apr. 2024 · Lineage tracing techniques allow one to map the genealogy of related cells, providing a critical tool for exploring the phylogenetic principles of biological …

Nettet6. apr. 2024 · Single cell lineage tracing reveals subclonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer. April 2024 DOI: 10.1101/2024.04.04.535588 Nettet10. jun. 2024 · Lineage tracing reveals metastatic dynamics. Lee E, Kang Y. Cancer Cell, 39(8):1050-1052, 24 Jun 2024 Cited by: 0 articles PMID: 34171265. Fsp1 …

Nettet24. jun. 2024 · Combining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In … Nettet19. okt. 2024 · Effective treatments for pancreatic ductal adenocarcinoma (PDAC) are lacking, and targeted agents have demonstrated limited efficacy. It has been speculated that a rare population of cancer stem cells (CSCs) drives growth, therapy resistance, and rapid metastatic progression in PDAC.

Nettet10. jun. 2024 · Of the cells that eventually became metastatic and grew in tissues and organs beyond the pancreas, the majority shared a common lineage, the researchers discovered. By building a precision tool...

Nettet1. mai 2024 · Major Finding: Cancer cells varied in metastatic potential before xenotransplantation; these differences were heritable. Concept: Complex routes were … mullion to helston busNettet13. apr. 2024 · Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states. Cancer Cell. 2024; 39: 1150-1162 ... Giving insight into the nature of drug-resistant “persister cells,” a combination of lineage tracing plus a dynamic reporter of cellular quiescence was used to show that cell-matrix interactions induced ... mullion surgery opening timesCombining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In … mullions windowNettet9. aug. 2024 · Lineage tracing reveals metastatic dynamics Eunmi Lee, Yibin Kang Combining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics . how to measure a cubic yard of gravelNettetThe development of PCa is strongly associated with loss of PTEN function, 17, 18 which frequency increases in metastatic PCa. 19, 20, 21 PTEN is a critical regulator of key cellular processes ... GSEA reveals positive enrichment of the hallmark androgen ... Lineage tracing K8-CreER T2;Pten Flox/Flox;R26-EYFP (K8PY) and control K8 … mullion the eagleNettet how to measure a cupNettet19. apr. 2024 · In the first study (Zhang et al., 2024), human metastatic breast and prostate cancer cell lines were injected orthotopically into mice and used to follow multi … mullion thickness