Laminin-332
WebLaminin-332, a rod-like heterotrimer composed of the laminin α3, β3, and γ2 chains, is a critical component of hemidesmosomes, adhesion complexes that attach the basal epidermal keratinocytes to the underlying dermal connective tissue [8,9,10]. The prominent role of laminin-332 for skin integrity stems from its ability to link two important ... WebApr 14, 2024 · The mucous membrane pemphigoid variant has antibodies to other BMZ components, including laminin-332 (previously known as laminin-5 and epiligrin), …
Laminin-332
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WebMay 1, 2024 · Laminin 332 is crucial in the biology of epithelia. This large extracellular matrix protein consists of the heterotrimeric assembly of three subunits – α3, β3, and γ2 – and its multifunctionality relies on a number of extracellular proteolytic processing events. Laminin 332 is central to normal epithelium homeostasis by sustaining cell ...
http://mdedge.ma1.medscape.com/dermatology/article/253386/pediatrics/iv-gentamicin-improves-junctional-epidermolysis-bullosa WebDec 15, 2009 · The distinct ways in which laminin-332 is deposited into the matrix of keratinocytes might simply be a secondary consequence of whether a cell is stationary or migratory. Alternatively, differences in laminin-matrix deposition by keratinocytes might be an important regulator of cell migratory behavior.
WebAnti-laminin-332-type MMP patients show severer and more refractory lesions on multiple mucous membranes, including larynx and conjunctivae [1,2,3]. Anti-laminin-332-type MMP has been reported to be frequently associated with solid malignant tumors, particularly gastric cancer [1,2,3]. Our case showed the widespread mucosal lesions from throat ... WebLaminin-332 is secreted by keratinocytes and is a heterodimer composed of alpha 3, beta 3, and gamma 2 chains. It plays an important role in integrity of the skin and mucosal …
WebMar 3, 2011 · The polymerization of laminin into a cell-associated network—a key step in basement membrane assembly—is mediated by the laminin amino-terminal (LN) domains at the tips of the three short arms of the laminin αβγ-heterotrimer. ... Matrix Biol 24: 326–332 [Google Scholar] Boraston AB, Bolam DN, Gilbert HJ, Davies GJ (2004) ...
WebLaminin 332, a large multidomain molecule involved in cell adhesion and matrix assembly, is a prominent component of squamous-cell carcinoma (SCC) extracellular matrix. The … historic tours of america key west jobsWebJul 6, 2024 · Background Mucous membrane pemphigoid is a group of chronic subepithelial autoimmune blistering diseases that mainly affect mucous membranes. Laminin 332-specific autoantibodies are present in approximately 1/3 of the patients, being associated with an increased risk of malignancy. Because of the severe complications, an early … historic town of vigan descriptionWebLaminin 332 is a major component of fibers called anchoring filaments, which connect the two layers of the basement membrane and help hold the skin together. Studies suggest … honda civic rs vs siWebJan 1, 2013 · Laminin 332, composed of the α3, β3 and γ2 chains, is an epithelial-basement membrane specific laminin variant. Its main role in normal tissues is the maintenance of epithelial-mesenchymal cohesion in tissues exposed to external forces, including skin and stratified squamous mucosa. honda civic r specsWebKey features and details Rabbit polyclonal to Laminin 5 Suitable for: WB, ELISA, IHC-Fr, ICC/IF, IP Reacts with: Mouse, Horse, Dog, Human Isotype: IgG Get better batch-to-batch reproducibility with a recombinant antibody Anti-Laminin alpha 5/LAMA5 antibody [EPR18919] (ab184330) historic tour vhcWebLaminin 332 is highly enriched in epithelial basement membranes. The importance of laminin 332 mediated adhesion in the skin is also evident in the human blistering … honda civic rs turbo wallpaperWebLaminin 332 is a major component of fibers called anchoring filaments, which connect the two layers of the basement membrane and help hold the skin together. Studies suggest … honda civic r type for sale