Klf2 endothelial cell

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August undefined, 2024

WebInterestingly, KLF2 inhibits endothelial cell activation by diverse proinflammatory stimuli, including interleukin (IL)-1β, tumor necrosis factor (TNF)α, lipopolysaccharide, and … WebNov 22, 2024 · Restoration of MAPK7 signaling abrogated these pathological effects in endothelial cells expressing miR-374b. Thus, our data suggest that the TGFβ-miR-374b-MAPK7 axis plays a key role in the induction of endothelial–mesenchymal transition during intimal hyperplasia and early lesion formation and might pose an interesting target for ...

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WebKLF2orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This characteristic is attributed to its ability to activate atheroprotective and inhibit atherogenic endothelial transcription programs. WebApr 11, 2024 · To systematically dissect the transcriptomic differences between homeostasis and chronic dry skin at the single-cell level, we carried out scRNA-seq on two biological mixed samples from each group, and each mixed sample contained three mice (Fig. 1 A).After quality control, we obtained 18,578 cells in the AEW groups and 24,160 … french rapid

KLF2 provokes a gene expression pattern that establishes …

WebThe large family of KLFs in humans includes 18 members, among which KLF2 and KLF4 are at the crossroads between endothelial cell mechanobiology and immunometabolism, which play important roles in ... WebJul 28, 2024 · Endothelial cells (ECs) are professional mechanosensing cells that constantly perceive and respond to the hemodynamic forces generated by blood flow. 1 The hemodynamic forces play a critical role in the development and geometric distribution of atherosclerosis, 2 a leading cause of death in patients with stroke and myocardial … WebLung Kruppel-like factor/KLF2 is highly expressed in the vascular endothelium (17). Systemic knockout of KLF2 results in embryonic death and abnormal vessel formation (17, 18). However, our understanding of the function and targets of KLF2 in endothelial biology have been lacking to date. We recently identiﬁed KLF2 as a novel transcriptional reg- french rap bands

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Krüppel-Like Factor 2 Is Required for Normal Mouse Cardiac

Webcultured endothelial cells, where it regulates a large number of vasoactive endothelial genes. Here, we show that Klf2 expression during development mirrors the rise of fluid shear forces, and that endothelial loss of Klf2 results in lethal embryonic heart failure due to a high-cardiac-output state. WebTzima et al showed that platelet and endothelial cell adhesion molecule-1 (PECAM-1, also called CD31), vascular ... showed significantly less induction of KLF2 expression than ciliated cells in the embryonic heart. 92 Primary cilia on ECs protrude into the vascular lumen and are molecular switches for Ca 2+ and NO signalling. 93 The ... fast pass new yorkWebJun 1, 2006 · The previously reported single-gene effects of mostly murine KLF2 6-10 in human endothelial cells have now been extended to over 1000 genes for human KLF2 … french rapier for sale

"WebJul 22, 2010 · KLF2 is a shear stress-induced factor that confers antiinflammatory and antithrombotic properties to the vascular EC. 15–21 However, despite the acknowledged importance of the endothelium in determining vascular barrier function, studies assessing the role of KLF2 (or any other member of this gene family) have not been reported. " - Klf2 endothelial cell

Klf2 endothelial cell

Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 ...

WebIn the procession of endothelial growth, KLF2 can act with ERG to activate the expression of Flk1 which is the receptor of vascular endothelial growth factor ... Similarly, miR-25–3p targets and represses the expression of KLF2 and KLF4 in endothelial cells, inhibiting the production of ZO-1, occluding, and Claudin5, ... WebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells.

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WebMar 4, 2024 · While endothelial KLF2 and endothelium-derived KLF2-induced miRNAs have homoeostatic, anti-proliferative effect on vascular endothelial and smooth muscle cells, direct activation of KLF2 in ... WebJul 25, 2005 · We hypothesized that Lung-Kruppel–like factor (LKLF/KLF2), a novel and potent regulator of endothelial gene expression, may mediate the downstream effects of statins. Here we report that statin-induced expression of endothelial NO synthase (eNOS) and thrombomodulin is KLF2 dependent.

WebNov 13, 2024 · Krüppel-like Factor 2 (KLF2) is an important indicator of the stemness of human MSCs (hMSCs) and as early vascularization is also critical for bone regeneration, we used KLF2 as a novel in vitro marker for … WebFeb 3, 2008 · KLF2 repressed the expression of several chemokine receptors, including CCR3 and CCR5. We thus conclude that KLF2 maintains proper T cell migration patterns …

WebOur studies suggest that endothelial Klf2 is expressed in response to fluid shear forces and is required for vascular hemodynamic regulation during development, but they do not … WebMay 25, 2024 · Kruppel-like factor 2 (KLF2) is a laminar flow-inducible transcription factor primarily expressed by endothelial cells that play an important role in the regulation of endothelial function [3,4]. Studies have shown that KLF2 induces eNOS expression and increases NO production in cultured human umbilical vein endothelial cells (HUVECs) and …

WebFeb 23, 2024 · Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results … french ranks ww1WebMay 5, 2004 · Overexpression of KLF2 in umbilical vein endothelial cells robustly induced endothelial nitric oxide synthase expression and total enzymatic activity. In addition, KLF2 … fast pass movie worldWebFeb 2, 2024 · KLF2 and KLF4 control endothelial identity and vascular integrity - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure you’re on a federal fast pass northern californiaWebJan 1, 2024 · Background & Aims. The transcription factor Krüppel-like factor 2 (KLF2), inducible by simvastatin, confers endothelial vasoprotection. Considering recent data … fast pass north carolinaWebFeb 18, 2024 · In human endothelial cells (ECs), acute inhibition of the HEG1-KRIT1 interaction by HKi2 increased KLF4 and KLF2 mRNA and protein levels, whereas a structurally similar inactive compound failed to do so. In zebrafish, HKi2 induced expression of klf2a in arterial and venous endothelium. french rapper cereal bowlWebOct 30, 2014 · KLF2 Controls Endothelial Cell Glycolysis and Angiogenic Phenotype Partly via PFKFB3 Inhibition PFKFB3 was recently shown to be an important regulator of endothelial cell glycolysis, 9 and we therefore hypothesized that inhibition of PFKFB3 could be the underlying mechanism by which KLF2 reduces endothelial cell glycolysis. fast pass ohioWebMar 4, 2024 · Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. fast pass nyc