Irf8 b cell
WebIRF8 (interferon regulatory factor 8; OMIM 601565, Chr. 16) is a transcription factor that is exclusively found in cells with hematopoietic lineage and is highly expressed in plasmacytoid dendritic cells ( Sichien et al., 2016 ). WebFig. 2 Functionally specialized conventional and non-conventional dendritic cell subsets and related lineages. cDC1. cDC1起源于CD34+造血干细胞,分化过程受包括干扰素调节因子8 (IRF8)在内的转录因子组合的调节;具有独特的C型凝集素受体CLEC9A和趋化因子XCR1的 …
Irf8 b cell
Did you know?
WebDec 12, 2024 · In B cells, PU.1 and IRF8 are expressed during early B-cell differentiation and IRF4 mainly at a later stage. Concomitant expression of PU.1, IRF4 and IRF8 is only observed in activated B cells 36. WebApr 14, 2024 · Targeting Dnmt1 in EC cultures potentiates a cytokine response that augments vascular cell:T-cell interactions. DNA hypomethylating agents such as 5-Azacytidine (5-Aza) that inhibit DNMT1 were ...
WebNational Center for Biotechnology Information WebApr 10, 2024 · Genetic classification helps to disclose molecular heterogeneity and therapeutic implications in diffuse large B-cell lymphoma (DLBCL). Using whole exome/genome sequencing, RNA-sequencing, and ...
WebDec 15, 2013 · IRF8 is a critical transcriptional regulator of immune system development and function. A recent study showed that marginal zone B cell and B1 B cell populations … WebInfection with ΔfliCΔfljB in Irf8 –/– BMDMs revealed reduced caspase-1 activation and cell death, suggesting that IRF8 is necessary for T3SS-dependent NLRC4 inflammasome …
WebNational Center for Biotechnology Information
WebApr 11, 2024 · CD8 + T cells are crucial for the clearance of viral infections. During the acute phase, proinflammatory conditions increase the amount of circulating phosphatidylserine + (PS) extracellular vesicles (EVs). These EVs interact especially with CD8 + T cells; however, it remains unclear whether they can actively modulate CD8 + T cell responses. In this … crystal\\u0027s isWebMar 2, 2016 · PU.1, IRF4 and IRF8 regulate early B-cell differentiation To investigate the pro/pre-B-cell compartment in more detail, BM derived CD19 + B220 + B cells of all mutant mice were... crystal\u0027s ikWebNov 15, 2008 · Exogenous IRF8 rescued B-cell development in IRF8-deficient HSCs, as indicated by the detection of large numbers of B220 + cells (Figure 6B). In contrast, the … dynamic joystick controllerWebIRF8 promotes the GC B cell response while inhibiting plasma cell differentiation through the induction of genes that maintain the B cell program and repression of genes that maintain... crystal\u0027s isWebApr 1, 2024 · In the TCGA dataset, IRF8 upregulation was most significantly associated with AML and diffuse large B-cell lymphoma, further supporting its utility as a marker of hematopoietic neoplasms [7]. In fact, the only sample positive for IRF8 on the carcinoma TMA turned out to be a testicular diffuse large B-cell lymphoma mistakenly added. … crystal\\u0027s ipWebNov 15, 2008 · Here we identify interferon regulatory factor 8 (IRF8) as another component of this complex, and show that it also modulates lineage choice by hematopoietic stem … dynamic kent.co inWeb(B) Relative reporter luciferase activity for Naip2 or Naip5 promoters in IRF8-overexpressing cells, presented as fold change with respect to empty vector (EV)-transfected cells. Data were normalized for transfection efficiency by normalizing firefly luciferase activity with renilla luciferase activity. crystal\\u0027s in