High-affinity choline transporter 1
WebA choline uptake system with a high affinity for choline has long been assumed to be present in cholinergic neurons. Very recently, the molecular entity for the high-affinity … WebThe transporter protein was cloned and identified by Okuda and co-workers in 2000, and shown to exhibit high-affinity, sodium-dependent choline uptake ( Km ~2 μM) which …
High-affinity choline transporter 1
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Web1 de jan. de 2005 · Kus, L. et al. Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system. J. Comp. Neurol. 463, 341–357 (2003).
Webcho-1 High-affinity choline transporter 1 [] Gene ID: 178274, updated on 22-Sep-2024 Summary Enables choline transmembrane transporter activity. Involved in choline … WebProtein target information for High affinity choline transporter 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay …
Web5 de mai. de 2024 · To examine the action of tetrahydropyrimidines on the nematode high-affinity choline transporter, we generated HEK293 cell lines stably expressing the high-affinity choline transporter from C. elegans (CHO-1), the ortholog of CHT1 (Okuda et al., 2000), and measured the high-affinity choline uptake activity in the presence of … WebCHT1 is a member of the SLC5 family of solute transporters and is assigned to SLC5A7 ( 12. ). Its amino acid sequence has 20–25% homology with that of other members of this family ( 13. ). It has been assumed that all members of the family possess a common 13-transmembrane domain core ( 14.
WebAt high concentrations, choline is transported primarily by a low-affinity and Na + -independent system that is inhibited by hemicholinium-3 (HC3) 10 with a high Ki of …
Web10 de jun. de 2005 · Maintenance of acetylcholine synthesis depends on the effective functioning of a high-affinity sodium-dependent choline transporter (CHT1). Recent studies have shown that this transporter is predominantly localized inside the cell, unlike other neurotransmitter transporters, suggesting that the trafficking of CHT1 to and from … how to set up tradfri remoteWeb1 de mar. de 2007 · Cholinergic innervation of the heart has been analyzed using cholinergic markers including acetylcholinesterase, choline acetyltransferase (ChAT), and vesicular acetylcholine transporter (VAChT). In the present study we demonstrate putative cholinergic nerves in the rat heart using an antibody to ChAT of a peripheral type … nothing wrong drawnWeb10 de jul. de 2015 · Synthesis and release of the neurotransmitter acetylcholine (ACh) is closely linked to the activity of the high-affinity choline transporter protein (CHT), but the impact of insulin receptor signaling and neuronal insulin resistance on these aspects of cholinergic function are unknown. how to set up tracker on iphoneWeb29 de jul. de 2014 · Highaffinity choline transporter 1 is involved in choline transport from the extracellular space to the neuron (48). Innexin 2 is required for the regulation of … how to set up trading botWebThe molecular entity for the high-affinity choline transporter was identified and is designated CHT1, which mediates Na+- and Cl−-dependent choline uptake with high sensitivity to hemicholinium-3 and has been characterized both at the molecular and functional levels. The cholinergic neurons have long been a model for biochemical … nothing wrong numberWeb1 de mai. de 1990 · It is demonstrated that these two affinity states of [3H]HC‐3 binding are totally interconvertible; addition of 0.1 mM ATP in the binding assay medium … nothing wrong celebrating simple lifeWeb3 de nov. de 2000 · The presence of the high-affinity choline transporter Choline transporter 1 in nerve fibers and epithelial cells in the human and rat skin supporting the pivotal role of this transporter in both the neuronal and non-neuronal cholinergic system of the skin is shown. 47 PDF View 3 excerpts, cites background how to set up trading view